Article
Clinical and functional relevance of melanocortin-4 receptor variants in obese German children.
Hormone research in paediatrics - 1 Jan 2012
Melchior Christin, Schulz Angela, Windholz Jan, Kiess Wieland, Schöneberg Torsten, Körner Antje
Abstract excerpt
BACKGROUND: Variants in the melanocortin-4 receptor (MC4R) gene are the most frequent cause of monogenic obesity. The relevance of MC4R variations with respect to clinical phenotype and biochemical function remains controversial. METHODS: We sequenced the MC4R gene in 510 overweight/obese children. The clinical phenotype was assessed in a case-control setting matched for age, gender, puberty and body mass index....
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