Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.

Diabetes - 1 Oct 2005

Bell Christopher G, Meyre David, Samson Chantal, Boyle Cliona, Lecoeur Cécile, Tauber Maïte, Jouret Béatrice, Jaquet Delphine, Levy-Marchal Claire, Charles Marie Aline, Weill Jacques, Gibson Fernando, Mein Charles A, Froguel Philippe, Walley Andrew J

Abstract excerpt

Murine models have been highly effective in identifying the monogenic forms of human obesity discovered to date. Melanin-concentrating hormone receptor 1 (MCHR1) has been shown to be significant in the downstream orexigenic activity of the leptin-melanocortin pathway by such models. In this study, the human MCHR1 gene was extensively characterized by sequencing 3.5 kb of coding, untranslated and intronic regions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Linkage Disequilibrium

Share to Obesity, Morbid

Share to Odds Ratio

Share to Promoter Regions, Genetic

Share to Receptors, Somatostatin

Source

Identifiers

PMID: 16186414
DOI: 10.2337/diabetes.54.10.3049

Genes

MCHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.PMID 16186414Read ↗

Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.Semantic proximity Read ↗

Mutation analysis of the MCHR1 gene in human obesity.Semantic proximity Read ↗

Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.Semantic proximity Read ↗

Rare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset Severe Obesity.Semantic proximity Read ↗

Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.Semantic proximity Read ↗

Genetics of obesity.Semantic proximity Read ↗

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood ObesitySemantic proximity Read ↗

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.Semantic proximity Read ↗

Heterozygous rare genetic variants in non-syndromic early-onset obesitySemantic proximity Read ↗

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.Semantic proximity Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.