Article
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.
The Journal of clinical endocrinology and metabolism - 1 Sept 2003
Hinney Anke, Hohmann Sarah, Geller Frank, Vogel Constanze, Hess Claudia, Wermter Anne-Kathrin, Brokamp Britta, Goldschmidt Hanspeter, Siegfried Wolfgang, Remschmidt Helmut, Schäfer Helmut, Gudermann Thomas, Hebebrand Johannes
Abstract excerpt
We initially performed a mutation screen of the coding region of the MC4R in 808 extremely obese children and adolescents and 327 underweight or normal-weight controls allowing for a case-control study. A total of 16 different missense, nonsense, and frameshift mutations were found in the obese s...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.