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Article

Rare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset Severe Obesity.

Frontiers in endocrinology - 1 Jan 2020

Loid Petra, Mustila Taina, Mäkitie Riikka E, Viljakainen Heli, Kämpe Anders, Tossavainen Päivi, Lipsanen-Nyman Marita, Pekkinen Minna, Mäkitie Outi

Abstract excerpt

Context: The hypothalamic circuit has an essential role in the regulation of appetite and energy expenditure. Pathogenic variants in genes involved in the hypothalamic leptin-melanocortin pathway, including melanocortin-4-receptor (MC4R), have been associated with monogenic obesity. Objective: To determine the rate and spectrum of rare variants in genes involved in melanocortin pathway or hypothalamic development...

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Identifiers

PMID: 32153512
DOI: 10.3389/fendo.2020.00081
PMCID: PMC7047210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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