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Article

Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2010

Goldstein Carmit, Schroeder Jonathan C, Fortin Jean-Philippe, Goss Jennifer M, Schaus Scott E, Beinborn Martin, Kopin Alan S

Abstract excerpt

The melanin-concentrating hormone (MCH) receptor type 1 (MCHR1) is a seven-transmembrane domain protein that modulates orexigenic activity of MCH, the corresponding endogenous peptide agonist. MCH antagonists are being explored as a potential treatment for obesity. In the current study, we examined the pharmacological impact of 11 naturally occurring mutations in the human MCHR1. Wild-type and mutant receptors...

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Source

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Identifiers

PMID: 20833795
DOI: 10.1124/jpet.110.174029
PMCID: PMC2993548

Genes

MCHR1

Provenance

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