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Article

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

The Journal of biological chemistry - 26 Aug 2005

Chen Qinghua, Thorpe Jeffrey, Keller Jeffrey N

Abstract excerpt

Alpha-synuclein appears to play a role in mediating neurotoxicity in a number of neurodegenerative disorders, collectively referred to as synucleinopathies. Most of these disorders are associated with aging and a probable impairment of the proteasome-proteolytic pathway, although the relationship between aging, proteasome inhibition, and alpha-synuclein toxicity has not been fully elucidated. Recent studies...

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PMID: 15941712
DOI: 10.1074/jbc.M501308200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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