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Article

Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast

3 Jun 2011

Abstract excerpt

Hydroxyurea (HU) inhibits ribonucleotide reductase (RNR), which catalyzes the rate-limiting synthesis of deoxyribonucleotides for DNA replication. HU is used to treat HIV, sickle-cell anemia and some cancers. We found that, compared with vector control cells, low levels of alpha-synuclein (α-syn) protect S. cerevisiae cells from the growth inhibition and reactive oxygen species (ROS) accumulation induced by HU....

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PMID: 21642386
DOI: 10.1093/hmg/ddr246

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