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Article

Degradation of alpha-synuclein by proteasome.

The Journal of biological chemistry - 26 Nov 1999

Bennett M C, Bishop J F, Leng Y, Chock P B, Chase T N, Mouradian M M

Abstract excerpt

Mutations in alpha-synuclein are known to be associated with Parkinson's disease (PD). The coexistence of this neuronal protein with ubiquitin and proteasome subunits in Lewy bodies in sporadic disease suggests that alterations of alpha-synuclein catabolism may contribute to the pathogenesis of P...

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PMID: 10567343
DOI: 10.1074/jbc.274.48.33855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10567343-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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