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Article

Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue.

Neurotoxicity research - 1 Apr 2010

Dyllick-Brenzinger Melanie, D'Souza Cheryl A, Dahlmann Burkhardt, Kloetzel Peter-Michael, Tandon Anurag

Abstract excerpt

Defects in the 20S/26S proteasome and conformational changes in alpha-synuclein (alpha-syn) are implicated in the development of sporadic and familial cases of PD. The objective of this study was to evaluate whether alpha-syn affects proteolysis by the proteasome and, reciprocally, whether proteasome inhibition affects alpha-syn solubility and localization. Although alpha-syn directly inhibited purified 20S...

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PMID: 19653055
DOI: 10.1007/s12640-009-9094-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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