Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.

Gene - 20 Jun 2005

Wang Naizhen, Ahmed Salahuddin, Haqqi Tariq M

Abstract excerpt

The inducible IkappaB kinase (IKKi/IKKepsilon) is a recently described serine-threonine kinase that activates the transcription factors NFkappaB, interferon regulatory factor-3 (IRF3) and CCAAA/enhancer-binding protein (C/EBPdelta). Several inflammatory agents have been shown to induce the expression of the IKKi gene in macrophages and other cell types but the mechanism is unknown. We have found that the IKKi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaline Phosphatase
Share to Chondrocytes
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to I-kappa B Kinase

Share to Interleukin-1

Share to Oligonucleotides

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 15939554
DOI: 10.1016/j.gene.2005.04.013
PMCID: PMC1266289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.PMID 15939554Read ↗

Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.Semantic proximity Read ↗

Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis.Semantic proximity Read ↗

Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis.Semantic proximity Read ↗

Chromatin Structural Analyses of the Mouse Igκ Gene Locus Reveal New Hypersensitive Sites Specifying a Transcriptional Silencer and EnhancerSemantic proximity Read ↗

The IKK complex, a central regulator of NF-kappaB activation.Semantic proximity Read ↗

Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers.Semantic proximity Read ↗

Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo.Semantic proximity Read ↗

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.Semantic proximity Read ↗

The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.Semantic proximity Read ↗

Enhancers that regulate <i>TNF</i> gene transcription in human macrophages in response to TLR3 stimulationSemantic proximity Read ↗

Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis.Semantic proximity Read ↗

Identification of a novel regulatory element in the human interleukin 1 alpha (IL-1alpha) gene promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.