Article
Identification of a novel regulatory element in the human interleukin 1 alpha (IL-1alpha) gene promoter.
Cytokine - 7 Nov 2002
Zaldivar Frank, Nugent Diane J, Imfeld Karen, Berman Monique A
Abstract excerpt
Human interleukin 1alpha (IL-1alpha) is secreted by a variety of cell types including epithelial cells, endothelial cells, keratinocytes, adipocytes and activated monocytes/macrophages. IL-1alpha is a major player in immune and inflammatory responses, yet very little is known about its regulation. We have identified a novel regulatory sequence at -65 to -41 of the human IL-1alpha promoter using DNase I footprint...
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