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Article

Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.

The Journal of biological chemistry - 20 Jul 2007

Gloire Geoffrey, Horion Julie, El Mjiyad Nadia, Bex Françoise, Chariot Alain, Dejardin Emmanuel, Piette Jacques

Abstract excerpt

IKKalpha regulates many chromatin events in the nuclear phase of the NF-kappaB program, including phosphorylation of histone H3 and removal of co-repressors from NF-kappaB-dependent promoters. However, all of the nuclear functions of IKKalpha are not understood. In this study, using mouse embryonic fibroblasts IKKalpha knock-out and reexpressing IKKalpha after retroviral transduction, we demonstrate that IKKalpha...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17537731
DOI: 10.1074/jbc.M610728200

Genes

HDAC3

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Related research

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Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.PMID 17537731Read ↗

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.Semantic proximity Read ↗

Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.Semantic proximity Read ↗

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The IKK complex, a central regulator of NF-kappaB activation.Semantic proximity Read ↗

Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis.Semantic proximity Read ↗

Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.Semantic proximity Read ↗

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.Semantic proximity Read ↗

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.Semantic proximity Read ↗

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.Semantic proximity Read ↗

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.Semantic proximity Read ↗

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.Semantic proximity Read ↗

cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.Semantic proximity Read ↗

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