Article
The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2004
Yang Fan, Yamashita Junro, Tang Eric, Wang Hom-Lay, Guan Kunliang, Wang Cun-Yu
Abstract excerpt
The activation of the I-kappaB kinase (IKK) complex by TNF or LPS stimulates phosphorylation and degradation of I-kappaBalpha, leading to the nuclear translocation of NF-kappaB. The IKK complex is mainly composed of two catalytic subunits, IKKalpha and IKKbeta, and a chaperon subunit IKKgamma. Al...
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