Article

Enhancers that regulate <i>TNF</i> gene transcription in human macrophages in response to TLR3 stimulation

2022-06-15

Abstract excerpt

Macrophages play a critical role in inflammatory responses during infections. These cells are activated by infections through stimulation of TLRs expressed on their cell surface and produce pro-inflammatory cytokines, including TNF. However, distal enhancers that regulate TNF gene transcription in human macrophages have not been investigated. This study used an unbiased genomic approach to identify six candidate...

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Literature Corpus work: cf7e56e1-4eeb-58e7-a907-a438a2680949
DOI: 10.1101/2022.06.13.496019

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