Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

Article

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

Cancer research - 1 Sept 1991

Isaacs W B, Carter B S, Ewing C M

Abstract excerpt

Evidence supporting a broad role for the inactivation of the p53 gene in human tumorigenesis has been provided by studies showing that the p53 gene is mutated in many human cancers. In this study, we report on the mutational status of the p53 gene in prostate cancer cells and provide functional e...

Topics

Alleles
Amino Acid Sequence
Gene Amplification
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Male
Molecular Sequence Data
Mutation
Prostatic Neoplasms
Transfection

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