Article
An intron binding protein is required for transformation ability of p53.
Nucleic acids research - 11 Sept 1991
Beenken S W, Karsenty G, Raycroft L, Lozano G
Abstract excerpt
Regulatory elements in intron sequences have been identified for several eukaryotic genes. The fourth intron of p53 is known to increase expression of p53 in a position dependent manner. We asked whether p53 intron 4 sequences interacted with DNA binding proteins to exact their effect. Three overlapping DNA fragments spanning the 5' end of p53 intron 4 were determined to specifically interact with protein in...
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