Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An intron binding protein is required for transformation ability of p53.

Nucleic acids research - 11 Sept 1991

Beenken S W, Karsenty G, Raycroft L, Lozano G

Abstract excerpt

Regulatory elements in intron sequences have been identified for several eukaryotic genes. The fourth intron of p53 is known to increase expression of p53 in a position dependent manner. We asked whether p53 intron 4 sequences interacted with DNA binding proteins to exact their effect. Three overlapping DNA fragments spanning the 5' end of p53 intron 4 were determined to specifically interact with protein in...

Topics

Animals
Base Sequence
Blotting, Northern
Cell Line
Cell Transformation, Neoplastic
DNA-Binding Proteins
Gene Expression
Genes, p53
Guanidine
Guanidines
Introns
Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 1891364
DOI: 10.1093/nar/19.17.4747
PMCID: PMC328718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1891364-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

An intron binding protein is required for transformation ability of p53.PMID 1891364Read ↗

Identification of p53 as a Sequence-Specific DNA-Binding ProteinSemantic proximity Read ↗

Inhibition of the mutant p53 gene in transformation assays.Semantic proximity Read ↗

Cloning and characterization of murine p53 upstream sequences reveals additional positive transcriptional regulatory elements.Semantic proximity Read ↗

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain.Semantic proximity Read ↗

Distinct regions of p53 have a differential role in transcriptional activation and repression functions.Semantic proximity Read ↗

Inactivation of the p53 gene expression by a splice donor site mutation in a human T-cell leukemia cell line.Semantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

A Transcriptionally Active DNA-Binding Site for Human p53 Protein ComplexesSemantic proximity Read ↗

A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation.Semantic proximity Read ↗

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.Semantic proximity Read ↗

Scintillation proximity assay for DNA binding by human p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.