Analysis of p53 mutants for transcriptional activity.

doi:10.1128/mcb.11.12.6067-6074.1991

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Article

Analysis of p53 mutants for transcriptional activity.

Molecular and cellular biology - 1 Dec 1991

Raycroft L, Schmidt J R, Yoas K, Hao M M, Lozano G

Abstract excerpt

The wild-type p53 protein functions to suppress transformation, but numerous mutant p53 proteins are transformation competent. To examine the role of p53 as a transcription factor, we made fusion proteins containing human or mouse p53 sequences fused to the DNA binding domain of a known transcrip...

Topics

Animals
Cloning, Molecular
Gene Expression Regulation
Genes, p53
HeLa Cells
Humans
Mice
Mutation
Precipitin Tests
Recombinant Fusion Proteins
Temperature
Transcription, Genetic
Tumor Suppressor Protein p53

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