Article
In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.
The Journal of clinical investigation - 1 Jul 2005
Sereti Irini, Imamichi Hiromi, Natarajan Ven, Imamichi Tomozumi, Ramchandani Meena S, Badralmaa Yunden, Berg Steve C, Metcalf Julia A, Hahn Barbara K, Shen Jean M, Powers April, Davey Richard T, Kovacs Joseph A, Shevach Ethan M, Lane H Clifford
Abstract excerpt
Administration of IL-2 to HIV-infected patients leads to expansion of a unique subset of CD4CD45ROCD25 cells. In this study, the origin, clonality, and function of these cells were investigated. Analysis of TCR excision circles revealed that the CD4CD45ROCD25 cells were the product of peripheral expansion but remained polyclonal as determined by TCR repertoire analysis. Phenotypically, these cells were distinct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.