Article
The time is crucial for ex vivo expansion of T regulatory cells for therapy.
Cell transplantation - 1 Jan 2011
Marek Natalia, Bieniaszewska Maria, Krzystyniak Adam, Juścińska Jolanta, Myśliwska Jolanta, Witkowski Piotr, Hellmann Andrzej, Trzonkowski Piotr
Abstract excerpt
Ex vivo expanded CD4(+)CD25(high)CD127(-) T regulatory cells (Tregs) are recognized as a promising candidate for immunosuppressive therapy in humans. However, due to the plasticity of Tregs lineage and artificial environment present during ex vivo expansion, Tregs easily lose suppressive activity. Here, we followed expanding CD4(+)CD25(high)CD127(-) Tregs and their naive (CD45RA(+)) and memory-like (CD45RA(-))...
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