Article
CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jan 2004
Fu Shuang, Yopp Adam C, Mao Xia, Chen Dongmei, Zhang Nan, Chen Dan, Mao Minwei, Ding Yaozhong, Bromberg Jonathan S
Abstract excerpt
CD4+ CD25+ regulatory T cells (Treg) are potent suppressors, and play important roles in autoimmunity and transplantation. Recent reports suggest that CD4+ CD25+ Treg are not a homogeneous cell population, but the differences in phenotype, function, and mechanisms among different subsets are unknown. Here, we demonstrate CD4+ CD25+ Treg cells can be divided into subsets according to cell-surface expression of...
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