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Article

Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.

Cerebellum (London, England) - 1 Jan 2008

Garden Gwenn A, La Spada Albert R

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is unique among CAG/polyglutamine (polyQ) repeat diseases due to dramatic intergenerational instability in repeat length and an associated cone-rod dystrophy retinal degeneration phenotype. SCA7 is caused by a polyQ expansion in the protein ataxin-7. Like other neurodegenerative diseases caused by polyQ expansion mutations, the spectrum of clinical severity and disease...

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Identifiers

PMID: 18418675
DOI: 10.1007/s12311-008-0027-y
PMCID: PMC4195584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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