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Article

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

The Journal of biological chemistry - 12 Oct 2007

Young Jessica E, Gouw Launce, Propp Stephanie, Sopher Bryce L, Taylor Jillian, Lin Amy, Hermel Evan, Logvinova Anna, Chen Sylvia F, Chen Shiming, Bredesen Dale E, Truant Ray, Ptacek Louis J, La Spada Albert R, Ellerby Lisa M

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem, and retinal neurons. Although they share little sequence homology, proteins implicated in polyQ disorders have common properties beyond their characteristic polyQ tract. These include the production of proteolytic fragments, nuclear accumulation, and processing by caspases....

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PMID: 17646170
DOI: 10.1074/jbc.M705265200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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