Article
Coactivators for the orphan nuclear receptor RORalpha.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 1999
Atkins G B, Hu X, Guenther M G, Rachez C, Freedman L P, Lazar M A
Abstract excerpt
A mutation in the nuclear orphan receptor RORalpha results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORalpha contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORalpha coactivators using the minimal activation domain as bait in a two-hybrid screen. Several known and putative coactivators were...
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