Article
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.
Human molecular genetics - 15 Jun 2004
Helmlinger Dominique, Hardy Sara, Sasorith Souphatta, Klein Fabrice, Robert Flavie, Weber Chantal, Miguet Laurent, Potier Noëlle, Van-Dorsselaer Alain, Wurtz Jean-Marie, Mandel Jean-Louis, Tora Làszlò, Devys Didier
Abstract excerpt
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by a CAG repeat expansion in the SCA7 gene leading to elongation of a polyglutamine tract in ataxin-7, a protein of unknown function. A putative ataxin-7 yeast orthologue (SGF73) has been identified recently as a new component of the SAGA (Spt/Ada/Gcn5 acetylase) multisubunit complex, a coactivator required for transcription of a subset...
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