Article

Progressive degeneration in a new Drosophila model of Spinocerebellar Ataxia type 7

2023-11-23

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder resulting from abnormal expansion of polyglutamine (polyQ) in its disease protein, ataxin-7 (ATXN7). ATXN7 is part of Spt-Ada-Gcn5 acetyltransferase (SAGA), an evolutionarily conserved transcriptional coactivation complex with critical roles in chromatin remodeling, cell signaling, neurodifferentiation, mitochondrial health and autoph...

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Literature Corpus work: 739cbb12-f733-5672-b4fe-1a20c85ff010
DOI: 10.21203/rs.3.rs-3592641/v1

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