Article
Linkage disequilibrium maps and association mapping.
The Journal of clinical investigation - 1 Jun 2005
Morton Newton E
Abstract excerpt
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative...
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