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Article

Shaking the tree: mapping complex disease genes with linkage disequilibrium.

Lancet (London, England) - 1 Oct 2005

Palmer Lyle J, Cardon Lon R

Abstract excerpt

Much effort and expense are being spent internationally to detect genetic polymorphisms contributing to susceptibility to complex human disease. Concomitantly, the technology for detecting and genotyping single nucleotide polymorphisms (SNPs) has undergone rapid development, yielding extensive catalogues of these polymorphisms across the genome. Population-based maps of the correlations amongst SNPs (linkage...

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PMID: 16198771
DOI: 10.1016/S0140-6736(05)67485-5

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