Article
Linkage disequilibrium maps and disease-association mapping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Maniatis Nikolas
Abstract excerpt
Over the last few years, association mapping of disease genes has developed into one of the most dynamic research areas of human genetics. It focuses on identifying functional polymorphisms that predispose to complex diseases. Population-based approaches are concerned with exploiting linkage disequilibrium (LD) between single-nucleotide polymorphism (SNPs) and disease-predisposing loci. The utility of SNPs in...
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