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Article

Linkage disequilibrium and association mapping.

Annual review of genomics and human genetics - 1 Jan 2008

Weir B S

Abstract excerpt

Linkage disequilibrium refers to the association between alleles at different loci. The standard definition applies to two alleles in the same gamete, and it can be regarded as the covariance of indicator variables for the states of those two alleles. The corresponding correlation coefficient rho is the parameter that arises naturally in discussions of tests of association between markers and genetic diseases. A...

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PMID: 18505378
DOI: 10.1146/annurev.genom.9.081307.164347

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