Genetic association analysis: a primer on how it works, its strengths and its weaknesses.

Abstract excerpt

Currently, the most used approach to mapping disease genes is the genome wide association study, using large samples of cases and controls and hundreds of thousands of markers spread throughout the genome. This review focuses in explaining how an association study works, its strengths and its weaknesses, and the methods available to analyse the data. Issues related to sample size, genetic effect sizes, epistasis,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosomes, Human, Y
• Share to False Positive Reactions
• Share to Family