Article
Fine-scale structure of the genome and markers used in association mapping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Curtin Karen, Camp Nicola J
Abstract excerpt
In this chapter, mutation (specifically single-nucleotide polymorphisms, SNPs) and recombination will be covered in more detail, and the concepts of genotype and haplotype will be reviewed. Linkage disequilibrium (LD) describes the strength of a relationship between alleles at different loci. The definition for LD, its visual representation, and the calculation of statistics that measure LD will be presented. The...
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