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Article

Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.

Molecular biology of the cell - 1 Aug 2005

Palmer Laura K, Shoemaker Jessica L, Baptiste Beverly A, Wolfe Darren, Keil Ralph L

Abstract excerpt

Volatile anesthetics including isoflurane affect all cells examined, but their mechanisms of action remain unknown. To investigate the cellular basis of anesthetic action, we are studying Saccharomyces cerevisiae mutants altered in their response to anesthetics. The zzz3-1 mutation renders yeast isoflurane resistant and is an allele of GCN3. Gcn3p functions in the evolutionarily conserved general amino acid...

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Identifiers

PMID: 15930127
DOI: 10.1091/mbc.e05-02-0127
PMCID: PMC1182311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.PMID 15930127Read ↗

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