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Article

Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer.

Thyroid : official journal of the American Thyroid Association - 1 Jul 2010

Xing Mingzhao

Abstract excerpt

BACKGROUND: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer (FTC) and aggressive thyroid cancer, such as anaplastic thyroid cancer (ATC). As the drivers of this process, many genetic alterations activating the PI3K/Akt pathway have been identified in thyroid cancer in recent years. SUMMARY:...

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Source

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Identifiers

PMID: 20578891
DOI: 10.1089/thy.2010.1646
PMCID: PMC2935335

Genes

PTEN
RET
BRAF
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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