Article
PIK3CA mutation and amplification in human lung cancer.
Pathology international - 1 Oct 2007
Okudela Koji, Suzuki Masaya, Kageyama Shinji, Bunai Tomoyasu, Nagura Kiyoko, Igarashi Hisaki, Takamochi Kazuya, Suzuki Kazuya, Yamada Takeshi, Niwa Hiroshi, Ohashi Riuko, Ogawa Hiroshi, Mori Hiroki, Kitamura Hitoshi, Kaneko Takeshi, Tsuneyoshi Toshihiro, Sugimura Haruhiko
Abstract excerpt
To explore the significance of phosphatidylinositol-3-kinase, catalytic, alpha (PIK3CA) in the carcinogenesis in human lung, mutations and copy number changes were investigated in 148 Japanese patients with primary cancer of the lung. For biological validation, the effects of exogenously expressed wild-type and mutated PIK3CA were studied in an immortalized human airway epithelial cell line. Mutations in PIK3CA...
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