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Article

Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2007

Hou Peng, Liu Dingxie, Shan Yuan, Hu Shuiying, Studeman Kimberley, Condouris Stephen, Wang Yangang, Trink Ariel, El-Naggar Adel K, Tallini Giovanni, Vasko Vasily, Xing Mingzhao

Abstract excerpt

PURPOSE: To investigate the overall occurrence and relationship of genetic alterations in the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in thyroid tumors and explore the scope of this pathway as a therapeutic target for thyroid cancer. EXPERIMENTAL DESIGN: We examined collectively the major genetic alterations and their relationship in this pathway, including PIK3CA copy number gain and mutation, Ras...

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Source

Identifiers

PMID: 17317825
DOI: 10.1158/1078-0432.CCR-06-1125

Genes

BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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