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Article

Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer.

The Journal of clinical endocrinology and metabolism - 1 Jan 2008

Santarpia Libero, El-Naggar Adel K, Cote Gilbert J, Myers Jeffrey N, Sherman Steven I

Abstract excerpt

CONTEXT: Anaplastic thyroid carcinoma (ATC) can occur in the setting of differentiated thyroid carcinoma (DTC), which suggests a continuum in malignant progression from DTC to ATC. The Ras/Raf-MAPK and the phosphatidylinositol 3-kinase/Akt signaling pathways play critical roles in DTC tumorigenesis, but their roles in the pathogenesis of ATC are poorly defined. OBJECTIVE: Our objective was to explore the...

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Source

Identifiers

PMID: 17989125
DOI: 10.1210/jc.2007-1076

Genes

BRAF
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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