Article
Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers.
The Journal of clinical endocrinology and metabolism - 1 Aug 2008
Liu Zhi, Hou Peng, Ji Meiju, Guan Haixia, Studeman Kimberly, Jensen Kirk, Vasko Vasily, El-Naggar Adel K, Xing Mingzhao
Abstract excerpt
CONTEXT: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and follicular thyroid cancers [anaplastic thyroid cancer (ATC), follicular thyroid cancer (FTC)]. OBJECTIVE: The objective of the study was to explore a wide-range genetic basis for the involvement of these pathways in ATC. DESIGN: We examined...
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