Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification.

doi:10.1371/journal.pone.0049192

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Article

Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification.

PloS one - 1 Jan 2012

Xing Jeffrey C, Tufano Ralph P, Murugan Avaniyapuram Kannan, Liu Dingxie, Wand Gary, Ladenson Paul W, Xing Mingzhao, Trink Barry

Abstract excerpt

The proto-oncogene PIK3CA has been well studied for its activating mutations and genomic amplifications but not single nucleotide polymorphism (SNP) in thyroid cancer. We investigated SNP rs17849071 (minor allele G and major allele T) in PIK3CA in thyroid tumors in 503 subjects by PCR and sequencing of a region of intron 9 carrying this SNP. This SNP was found in both normal and thyroid tumor tissues as well as...

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PMID: 23185308
DOI: 10.1371/journal.pone.0049192
PMCID: PMC3504026

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