The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

Abstract excerpt

Constitutive expression of telomerase prevents senescence and crisis by maintaining telomere homeostasis. However, recent evidence suggests that telomerase is dynamically regulated in normal cells and also contributes to transformation independently of net telomere elongation. Here, we show that suppression of the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] expression abrogates...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosomal and Genetic Variations
• Share to DNA Repair Mechanisms
• Share to Telomeres, Telomerase, and Senescence