Article
Telomerase maintains telomere structure in normal human cells.
Cell - 25 Jul 2003
Masutomi Kenkichi, Yu Evan Y, Khurts Shilagardy, Ben-Porath Ittai, Currier Jennifer L, Metz Geoffrey B, Brooks Mary W, Kaneko Shuichi, Murakami Seishi, DeCaprio James A, Weinberg Robert A, Stewart Sheila A, Hahn William C
Abstract excerpt
In normal human cells, telomeres shorten with successive rounds of cell division, and immortalization correlates with stabilization of telomere length. These observations suggest that human cancer cells achieve immortalization in large part through the illegitimate activation of telomerase expression. Here, we demonstrate that the rate-limiting telomerase catalytic subunit hTERT is expressed in cycling primary...
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