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Article

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.

Nature genetics - 1 Sept 2000

Wong K K, Chang S, Weiler S R, Ganesan S, Chaudhuri J, Zhu C, Artandi S E, Rudolph K L, Gottlieb G J, Chin L, Alt F W, DePinho R A

Abstract excerpt

Telomeres are specialized nucleoprotein complexes that serve as protective caps of linear eukaryotic chromosomes. Loss of telomere function is associated with rampant genetic instability and loss of cellular viability and renewal potential. The telomere also participates in processes of chromosom...

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Identifiers

PMID: 10973255
DOI: 10.1038/79232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10973255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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