Article
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics - 1 Sept 2000
Wong K K, Chang S, Weiler S R, Ganesan S, Chaudhuri J, Zhu C, Artandi S E, Rudolph K L, Gottlieb G J, Chin L, Alt F W, DePinho R A
Abstract excerpt
Telomeres are specialized nucleoprotein complexes that serve as protective caps of linear eukaryotic chromosomes. Loss of telomere function is associated with rampant genetic instability and loss of cellular viability and renewal potential. The telomere also participates in processes of chromosomal repair, as evidenced by the 'capture' or de novo synthesis of telomere repeats at double-stranded breaks and by the...
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