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Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

9 May 2016

Abstract excerpt

Chromosome-shortening is characteristic of normal cells, and is known as the end replication problem. Telomerase is the enzyme responsible for extending the ends of the chromosomes in de novo synthesis, and occurs in germ cells as well as most malignant cancers. There are three subunits of telomerase: human telomerase RNA (hTERC), human telomerase associated protein (hTEP1), or dyskerin, and human telomerase...

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Share to Circadian rhythm and melatonin
Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 27242892
DOI: 10.3389/fgene.2016.00083

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