Article
Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability.
Oncogene - 14 Jan 2016
Fleisig H B, Hukezalie K R, Thompson C A H, Au-Yeung T T T, Ludlow A T, Zhao C R, Wong J M Y
Abstract excerpt
Reactivation of telomerase reverse transcriptase (TERT) expression is found in more than 85% of human cancers. The remaining cancers rely on the alternative lengthening of telomeres (ALT), a recombination-based mechanism for telomere-length maintenance. Prevalence of TERT reactivation over the ALT mechanism was linked to secondary TERT function unrelated to telomere length maintenance. To characterize this...
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