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Article

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

1 Jan 2010

Abstract excerpt

Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival, and they play important roles in development, aging, and cancer. Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene (hTERT) is a complex process in normal cells and many cancer cells. In addition to a number of transcriptional...

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PMID: 21203995
DOI: 10.1007/s13238-010-0014-1

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