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Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis

24 Nov 2015

Abstract excerpt

Telomeres are nucleoprotein complexes comprised of tandem arrays of repetitive DNA sequence that serve to protect chromosomal termini from inappropriate degradation, as well as to prevent these natural DNA ends from being recognized as broken DNA (double-strand breaks) and triggering of inappropriate DNA damage responses. Preservation of telomere length requires telomerase, the specialized reverse transcriptase...

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PMID: 26636039
DOI: 10.3389/fonc.2015.00257

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