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Article

Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells.

Cancer biology & therapy - 1 Jan 2000

Hauguel Travis, Bunz Fred

Abstract excerpt

One of the most consistent differences between cancer cells and normal somatic cells is the continuous expression of telomerase, an enzyme that is important for maintenance of chromosome ends, or telomeres. It is believed that telomerase expression allows cancer cells to maintain their telomeres after many cell divisions and thereby avoid replicative senescence. We have tested this hypothesis by targeting the...

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PMID: 14688476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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