Article
LRRK2 R1441G in Spanish patients with Parkinson's disease.
Neuroscience letters - 15 Jul 2005
Mata Ignacio F, Taylor Julie P, Kachergus Jennifer, Hulihan Mary, Huerta Cecilia, Lahoz Carlos, Blazquez Marta, Guisasola Luis M, Salvador Carlos, Ribacoba Renee, Martinez Carmen, Farrer Matthew, Alvarez Victoria
Abstract excerpt
Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2; PARK8) have been implicated in autosomal dominant, late-onset Parkinson's disease (PD). The LRRK2 4321C>G (R1441G) mutation was originally identified in Spanish families originating from the Basque region. Within this ethnicity, Lrrk2 R...
Topics
- Adult
- Aged
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Polymerase Chain Reaction