Article
Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain.
European journal of neurology - 1 Aug 2009
Gao L, Gómez-Garre P, Díaz-Corrales F J, Carrillo F, Carballo M, Palomino A, Díaz-Martín J, Mejías R, Vime P J, López-Barneo J, Mir P
Abstract excerpt
BACKGROUND AND PURPOSE: Mutations in leucine-rich repeat kinase 2 (LRRK2) gene are associated with both familial and idiopathic Parkinson's disease (PD), whereas mutations in PARK2 (PARKIN) gene result in early onset recessive PD. Here, the objectives were to determine the frequency of LRRK2 G201...
Topics
- Adult
- Age of Onset
- DNA Mutational Analysis
- Female
- Gene Frequency
- Haplotypes
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Mutation, Missense