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Article

Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain).

Movement disorders : official journal of the Movement Disorder Society - 30 Oct 2010

Ruiz-Martínez Javier, Gorostidi Ana, Ibañez Berta, Alzualde Ainhoa, Otaegui David, Moreno Fermin, López de Munain Adolfo, Bergareche Alberto, Gómez-Esteban Juan Carlos, Martí Massó José F

Abstract excerpt

The LRRK2 R1441G mutation was first identified in Basque families and it is responsible for 46% of familial Parkinson's disease (PD) and for 2.5% of sporadic PD in the PD population of Basque ascent. The aim of this study was to determine LRRK2 R1441G penetrance in PD in the Basque Country (Spain) to help in a more accurate genetic counseling. A total of 59 sibships containing 244 individuals, with a total of 40...

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PMID: 20721916
DOI: 10.1002/mds.23278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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