Article
Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.
Neurogenetics - 1 Oct 2009
Mata Ignacio F, Hutter Carolyn M, González-Fernández María C, de Pancorbo Marian M, Lezcano Elena, Huerta Cecilia, Blazquez Marta, Ribacoba Renee, Guisasola Luis M, Salvador Carlos, Gómez-Esteban Juan C, Zarranz Juan J, Infante Jon, Jankovic Joseph, Deng Hao, Edwards Karen L, Alvarez Victoria, Zabetian Cyrus P
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene together represent the most common genetic determinant of Parkinson's disease (PD) identified to date. The vast majority of patients with LRRK2-related PD reported in the literature carry one of three pathogenic substitutions: G2019S, R1441C, or R1441G. While G2019S and R1441C are geographically widespread, R1441G is most prevalent in the Basque Country...
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