Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.

doi:10.1007/s10048-009-0187-z

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Article

Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.

Neurogenetics - 1 Oct 2009

Mata Ignacio F, Hutter Carolyn M, González-Fernández María C, de Pancorbo Marian M, Lezcano Elena, Huerta Cecilia, Blazquez Marta, Ribacoba Renee, Guisasola Luis M, Salvador Carlos, Gómez-Esteban Juan C, Zarranz Juan J, Infante Jon, Jankovic Joseph, Deng Hao, Edwards Karen L, Alvarez Victoria, Zabetian Cyrus P

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene together represent the most common genetic determinant of Parkinson's disease (PD) identified to date. The vast majority of patients with LRRK2-related PD reported in the literature carry one of three pathogenic substitutions: G2019S, R14...

Topics

Adult
Age of Onset
Aged
Amino Acid Substitution
Female
Founder Effect
Genetic Markers
Genetic Predisposition to Disease
Haplotypes
History, Medieval

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Male

Middle Aged

Parkinson Disease

Point Mutation

Polymorphism, Single Nucleotide

Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19308469
DOI: 10.1007/s10048-009-0187-z
PMCID: PMC2821036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19308469-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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